Penn Center for Innovation

Turning back the clock on a severe vision disorder

Posted on March 31, 2021 — Jessica Jones Gupta

Gene therapy triggered the regrowth of healthy photoreceptor cells and restored vision in dogs with a severe form of Leber congenital amaurosis.

Gustavo Aguirre and William Beltran, veterinary ophthalmologists and vision scientists at the School of Veterinary Medicine, have studied a wide range of different retinal blinding disorders. But the one caused by mutations in the NPHP5 gene, leading to a form of Leber congenital amaurosis (LCA), is one of the most severe.  They were 2019 winners of the PCI Inventors of the Year Award.

Read more in Penn Today

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