PCI Startup Portfolio

Startup companies established by Penn or with founding technology developed at Penn

Penn inventors and researchers can choose to form startup companies leveraging their own expertise and partners or with direct support from Penn.  PCI provides a number of programs that support startup formation through our PCI Ventures group, those resources can be found here.

Additionally, PCI works closely with Penn faculty to advise them on how to create a startup company as well as with new companies to license Penn technology. 

Search our portfolio below, and click on each startup to learn more about their technologies, inventors, and whether they are looking for investors or new employees.

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Advac Therapeutic

Development of vaccines and therapeutics for the treatment of infectious diseases and cancers


A revolutionary smart training system for high-performance athletes


Wearing physiological sensors to monitor for exacerbations of heart failure

Axonova Medical

Proprietary technology platform allowing stretch growth of axon bundles for use as fully functional grafts to address peripheral and CNS neuropathies.


Heat-based technology for wound healing

Cantius Therapeutics


Cantius Therapeutics has a unique and well-placed strategy to treat cachexia and block nausea/emesis.

Carisma Therapeutics

Cellular immunotherapy for solid tumors.

Carousel Therapeutics

Carousel Therapeutics is developing a universal CAR-T targeting system for the treatment of relapse and refractory solid tumors.


Developing CAR regulatory T cells to treat atherosclerosis and other cardiovascular diseases.


Catheters using real time anatomic video feedback and fluoroscopic assistance for precise gene therapy delivery and treatment of other disorders of the central nervous system

Chip Diagnostics

Lab-on-a-chip platform addressing the need for rapid, inexpensive, and highly sensitive diagnostics


Affordable, mobile, comfortable, sustained, research-grade, brain state monitoring on the go

Daimroc Imaging

Using Argentavue, a silver nanoparticle contrast agent for breast cancer imaging


Developing magnetic materials, processes, and device designs that enable integration of magnetic components with silicon semiconductor devices


Developing novel enteric bypass solutions to change the paradigm of enterocutaneous fistula management


Novel epigenetic therapeutics to treat complex psychiatric disorders


Developing a diagnostic test to predict a patient’s responsiveness to cancer immunotherapy, with a focus on checkpoint inhibitor therapies.



Analyzes dynamic blood flow as a diagnostic technique in trauma, ER, and clinical settings

Ghost Robotics

Building customizable robotic machines highly adept at perceiving tactile sensations


Hydropore is a clean technology start-up developing hydrogen fuel pellets for drones.


This app provides data-driven insights and recommendations to help people get their most, best sleep.


Developing small molecule PARP inhibitors for the treatment of cancer and neurological disorders.

Infini – Fluidics


Industry 4.0 in pharmaceutical and chemical manufacturing processes


Implantable tissue engineered brain pathways for neurodegenerative disorders.



An innovative and broadly-applicable point-of-care platform to detect ultra-low concentrations of disease biomarkers.

Jericho Music Labs

A mobile platform for copyrighted music distribution

JT Me-Sh Diagnostics

Developing a novel point-of-care device to evaluate an individual’s exposure to radiation.



Targeted therapeutics from flaxseed derivatives


Advanced technology for limb salvage and reconstruction


Developing a G protein-coupled estrogen receptor (GPER) agonist with applicability across a range of cancers.

Liquid Biotech

Diagnostic blood test for sensitive detection of circulating tumor cells.

Mechano Therapeutics

A therapeutic delivery platform using mechanically-activated microcapsule technology


Applying portable electronic technology to advance the potential of endoscopic imagery



MyoArete is developing newly identified utrophin upregulation therapies that treat all Duchenne Muscular Dystrophy patients.



Robust wearable monitors to rapidly identify critically important neurological events such as stroke

Neurokappa Therapeutics

Treatments for cerebral vascular spasm using salvia divinosum

Nia Therapeutics

Developing responsive neurostimulation therapies for patients with dementia and other memory disorders.


Catheter based retrieval systems designed to recovered malposition cardiovascular devices


Software and sensor technology to enhance productivity, increase efficiency and automate processes for the construction, mining and infrastructure industries


Developing medical devices for the prevention of thrombosis


Diagnostic and prognostic tools for the treatment of acute musculoskeletal injuries, chronic orthopedic pathologies, and bone implant complications

Osteome Synthetica

Developing personalized synthetic bone substitutes that are precision printed.


A novel approach to correct skeletal deformities and deficiencies using a fully implantable, magnetically-driven, bony distraction device

Paradigm Surgical

Prophylactic mesh augmentation systems for fascial reinforcement


Novel therapeutic to prevent acute lung injury, the major cause of death with sepsis.

Pinpoint Therapeutics

Developing novel autophagy inhibitor molecules for cancer treatment.


Biodegradable gold nanoparticles to diagnose and treat diseases via enhanced x-ray attenuation


Developing microRNA therapies to treat myocardial infarction, prevent remodeling, and regenerate tissue


Advanced body-wide analysis of medical imagery for clinical and research purposes

Recupero Robotics

Robotics for improved physical therapy

Ribovate Therapeutics

Ribovate is developing the next generation targeted mRNA-lipid nanoparticle therapeutic platform.


Wearable device for respiratory assistance in COPD patients

Sapience Leadership

Consulting services on curricula, operational issues, and strategic planning


Technology-enhanced immersive learning solutions to leadership development for educational and other organizations



Improving neurosurgery and neurosurgeons through anatomical pattern recognition assistance

Vellum Biosciences

Non-invasive imaging diagnostic to differentiate cancer, inflammation, and infection

Veltion Therapeutics

Novel approaches for cancer treatment by targeting the Integrated Stress Response and its role in tumor as well as stroma adaptation to stress

Verix Health

High performance steerable needle technology


Using novel phage-display techniques to develop reagents and therapeutics for veterinary medicine

Vital Start Health

Empowering clinicians and caregivers by giving them a digital platform to improve neonatal care


Creating a groundbreaking 3D tissue culture pipeline and statistical inference engine to test drugs, biologics, and immunotherapies directly on ultra-realistic , bioengineered human tissues.

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