Phenotype, proliferation and exhaustion Archives - Penn Center for Innovation

HVEM and BTLA modulation to enhance CART immunotherapy

February 24, 2026 |

Improvement in efficacy of adoptive transfer of T cells by the genetic addition of a small peptide encoding a protein kinase A regulatory subunit I anchoring disruptor (RIAD)

February 24, 2026 |

Modulation of methylcytosine dioxygenases for improving the therapeutic efficacy of gene-modified antigen-specific T cells

February 24, 2026 |

Combination of CART and SMAC mimetics for cancer treatment

February 24, 2026 |

Knockout of Regnase-1 and Roquin-1 alone or together to enhance CAR T cell activity

February 24, 2026 |

Compositions and methods for enhancing the anti-tumor activity of CAR T cells by co-expression of Ch25h

February 24, 2026 |

Engineered expression of cell surface and secreted sialidase by CAR T cells for increased efficacy in solid tumors

February 24, 2026 |

Enhancing CAR T cell efficacy using Neuraminidase as well as Galactose Oxidase

February 24, 2026 |

Selective stimulation of T cells in solid tumors using oncolytic viral delivery of orthogonal IL-2

February 24, 2026 |

CRISPR mediated knock out of SOX4 and ID3 delays T cell dysregulation induced by chronic antigen exposure

February 24, 2026 |

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