Deciphering a cancer treatment’s dark side

A cancer therapy that harnesses the immune system to combat tumors has come with some steep learning curves—among them, how to manage the treatment’s sometimes risky side effects. One common hazard of CAR-T cell therapy, as it’s known, is a dramatic inflammatory response, which can trigger symptoms from high fevers to organ failure. Research published today from a team of scientists in China seeks to untangle what’s happening at the cellular level during this response, in hopes of ultimately finding ways to prevent it.

This article features a quote from Saar Gill, MD, PhD, Penn Medicine faculty member.

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